Predictive value of spleen stiffness in hepatocellular carcinoma

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

CT-Value (△HU and CT-Value ratioin) differential diagnosis of small hepatocellular carcinoma from focal nodular hyperplasia

Background: The objective was to explore the value of the CT value difference (△HU) and CT value ratio (CVR) between the hepatic arterial (AP), portal (PP), and delayed phases (DP) to differentiate the small Hepatocellular Carcinoma (SHCC, ≤ 3 cm) from the small Focal nodular hyperplasia (SFNH, ≤ 3 cm). Materials and Methods: All the lesions were confirmed by clinically and/or pathologically an...

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

Possible protective effects of resveratrol in hepatocellular carcinoma

Objective(s): Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular carcinoma (HCC) induced by  diethylnitrosamine (D...